Melanotan I (MT1) 10mg

Melanotan I Peptide

Melanotan I (MT1), also known as Afamelanotide, is a synthetic analog of the naturally occurring alpha-melanocyte-stimulating hormone (α-MSH). It functions primarily as a selective agonist of the melanocortin-1 (MC1) receptor, the receptor responsible for regulating melanin synthesis within melanocytes. Developed through research into melanocortin biology, Melanotan I was engineered to provide greater stability and a longer biological half-life than endogenous α-MSH, allowing researchers to investigate its effects on pigmentation and photoprotection more effectively.

Unlike Melanotan II, which activates multiple melanocortin receptor subtypes, Melanotan I demonstrates a strong preference for MC1 receptors. This receptor selectivity results in a more targeted stimulation of melanogenesis with reduced activity at receptors associated with appetite regulation and sexual function. Because of these characteristics, Melanotan I has become an important subject in studies examining pigmentation disorders, ultraviolet (UV) protection, and skin biology.

---

Overview

Melanotan I remains an important research peptide due to its ability to selectively activate the melanocortin pathway involved in melanin production. By stimulating MC1 receptors on melanocytes, the peptide promotes the synthesis of eumelanin—the darker form of melanin associated with increased natural protection against ultraviolet radiation. Researchers continue to investigate how enhanced melanin production may contribute to reducing UV-induced oxidative stress and DNA damage in the skin.

Beyond its effects on pigmentation, Melanotan I has been extensively studied for its potential role in photoprotection and rare photosensitivity disorders. Its selective receptor profile has made it particularly valuable in research aimed at understanding the relationship between melanocortin signaling, skin pigmentation, and cellular defense mechanisms. Scientists continue to explore additional applications involving inflammatory pathways and skin health, although these areas remain under active investigation.

Chemical Makeup

• Molecular Formula: C78H111N21O19
• Molecular Weight: 1646.85 g/mol
• Other Known Titles: Melanotan I, MT-I, MT-1, Afamelanotide, [Nle4,D-Phe7]-α-MSH

---

Research Studies and Clinical Trials

Melanogenesis and UV Protection

Melanotan I has been widely investigated for its ability to stimulate eumelanin production through selective activation of MC1 receptors. Clinical and preclinical studies have demonstrated increased skin pigmentation with reduced dependence on ultraviolet exposure. Researchers continue to evaluate whether increased melanin levels may help protect skin cells from UV-induced DNA damage, oxidative stress, and long-term photodamage.

Erythropoietic Protoporphyria (EPP)

One of the most extensively studied applications of Melanotan I has been in erythropoietic protoporphyria (EPP), a rare genetic disorder characterized by extreme sensitivity to sunlight. By increasing melanin production, researchers observed that the peptide may improve tolerance to sunlight and reduce phototoxic reactions. These investigations ultimately led to the development of Afamelanotide for specific clinical applications in certain regions.

Pigmentation Disorders

Researchers continue to investigate Melanotan I for its potential role in conditions involving impaired pigmentation, including vitiligo and other hypopigmentation disorders. Experimental studies suggest that selective MC1 receptor activation may enhance melanocyte function and support repigmentation when combined with established therapeutic approaches.

Anti-Inflammatory and Skin Biology Research

Beyond pigmentation, melanocortin signaling has been implicated in the regulation of inflammatory responses. Laboratory studies suggest that MC1 receptor activation may influence cytokine production, oxidative stress, and immune cell activity within the skin. Although these findings remain preliminary, they continue to support further investigation into the broader biological functions of Melanotan I.

---

Disclaimer: Melanotan I is an experimental compound. It is not approved by the FDA or other major health authorities for human use. This description is for informational purposes based on current research data and does not constitute medical advice. Melanotan I is available for research and laboratory purposes only.