Melanotan II (MT2) 10mg

Melanotan II Peptide

Melanotan II (MT2) is a synthetic cyclic heptapeptide analog of the naturally occurring alpha-melanocyte-stimulating hormone (Alpha-MSH). It functions as a non-selective agonist of melanocortin receptors, specifically targeting MC1, MC3, MC4, and MC5. Developed originally at the University of Arizona, the peptide was engineered to provide a more potent and stable alternative to natural melanotropins, which have a very short half-life in the body.

Researchers designed Melanotan II by modifying the native Alpha-MSH sequence to include a lactam bridge, which cyclizes the molecule. This structural modification enhances its resistance to enzymatic degradation and significantly increases its binding affinity to melanocortin receptors. While the primary endogenous role of Alpha-MSH is to regulate skin pigmentation, MT-II’s broader receptor activation profile extends its physiological influence to energy homeostasis, sexual function, and inflammation.

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Overview

Melanotan II is a subject of ongoing laboratory investigation due to its multi-systemic effects. Unlike single-target peptides, MT-II’s interaction with the melanocortin system triggers a cascade of biological responses. Its activation of the MC1 receptor stimulates melanogenesis—the process by which melanocytes produce eumelanin—while its interaction with the central MC4 receptor has been observed to influence appetite and metabolic rate.

Preliminary research indicates that MT-II may cross the blood-brain barrier, allowing it to modulate central nervous system pathways. Scientists are evaluating its potential in several experimental contexts, including the treatment of erythropoietic protoporphyria (EPP), metabolic syndrome, and sexual dysfunction. Because of its potency, researchers continue to study the dose-response relationship to better understand the balance between its stimulatory effects and its impact on systemic homeostasis.

Chemical Makeup

• Molecular Formula: C50H69N15O9
• Molecular Weight: 1024.18 g/mol
• Other Known Titles: MT-II, MT-2, Cyclo-[Nle4, Asp5, D-Phe7, Lys10]Alpha-MSH(4-10)

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Research Studies and Clinical Trials

Melanogenesis and Photoprotection

In early clinical evaluations, researchers observed that Melanotan II effectively increased melanin density in human subjects without the requirement for high-level UV exposure. By mimicking the action of Alpha-MSH on MC1 receptors, the peptide initiates the synthesis of dark pigment (eumelanin). This has led researchers to investigate its potential as a “photoprotective” agent, theorizing that increased melanin may provide a biological shield against UV-induced DNA damage and skin malignancies.

Influence on Sexual Function and Arousal

One of the most documented observations during MT2 research was its impact on sexual arousal. Studies targeting the MC3 and MC4 receptors in the brain found that MT2 could induce spontaneous erections in male subjects and increase desire in female subjects. This led to the development of related analogs, though researchers continue to study MT-II itself to understand the neural pathways governing the melanocortin-mediated sexual response.

Appetite Suppression and Energy Balance

Laboratory studies involving the MC4 receptor have highlighted MT-II’s role in metabolic regulation. Activation of MC4R in the hypothalamus is known to suppress food intake and increase energy expenditure. In animal models, administration of MT2 has been shown to reduce adiposity and improve lipid profiles, leading researchers to explore its utility in understanding the genetic components of obesity and satiety signaling.

Cardiovascular and Systemic Observations

Research monitoring the physiological impact of Melanotan II has noted transient increases in blood pressure and heart rate in some subjects. These effects are thought to be mediated by the sympathetic nervous system via MC4 receptor activation. Additionally, some studies have noted “stretching and yawning” behaviors in research subjects, illustrating the complex behavioral effects of central melanocortin receptor stimulation.

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Disclaimer: Melanotan II is an experimental compound. It is not approved by the FDA or other major health authorities for human use. This description is for informational purposes based on current research data and does not constitute medical advice. Melanotan II is available for research and laboratory purposes only.